Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …

Phagocytic clearance of dying cells, termed efferocytosis, is essential for maintaining tissue
homeostasis, yet our understanding of efferocytosis regulation remains incomplete. Here we …

Protein trafficking requires coat complexes that couple recognition of sorting motifs in
transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo …

The ability of endolysosomal organelles to move within the cytoplasm is essential for the
performance of their functions. Long-range movement involves coupling of the …

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …

Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

Actively maintained close appositions between organelle membranes, also known as
contact sites, enable the efficient transfer of biomolecules between cellular compartments …

Polyphosphoinositides (PPIns) are signalling messengers representing less than five per
cent of the total phospholipid concentration within the cell. Despite their low concentration …