We have identified, characterized and cloned human, mouse and chicken cDNA of a novel
protein that binds to the Src homology domain 3 (SH3) of the Yes proto-oncogene product …

Although intuitively clear, the concept of the protein domain eludes strict and universally
accepted definition. At the recent Meeting on Perspectives of Protein Engineering (held from …

Amyloid-β precursor protein (APP), a widely expressed cell-surface protein, is cleaved in the
transmembrane region by γ-secretase. γ-Cleavage of APP produces the extracellular …

Life and death fate decisions allow cells to avoid massive apoptotic death in response to
genotoxic stress. Although the regulatory mechanisms and signalling pathways controlling …

The β-amyloid precursor protein (APP) is a ubiquitous receptor-like molecule without a
known function. However, the recent recognition that APP and Notch undergo highly similar …

The phosphotyrosine interaction (PI) domains (also known as the PTB, or phosphotyrosine
binding, domains) of Shc and IRS-1 are recently described domains that bind peptides …

The physiological functions of the beta-amyloid precursor protein (APP) may include nuclear
signaling. To characterize the role of the APP adaptor proteins Fe65, Jip1b, X11α (MINT1) …

Apolipoprotein E, α 2-macroglobulin, and amyloid precursor protein (APP) are involved in
the development of Alzheimer's disease. All three proteins are ligands for the low density …

The low density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional cell
surface receptor that interacts through its cytoplasmic tail with adaptor and scaffold proteins …

Fe65 is a protein mainly expressed in several districts of the mammalian nervous system.
The search of protein sequence data banks revealed that Fe65 contains two …