[HTML][HTML] Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

D Liu, SY Huang, JH Sun, HC Zhang, QL Cai… - Military Medical …, 2022 - Springer
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-
threatening organ dysfunction caused by a dysregulated host response to infection. It is also …

Cytokines in sepsis: potent immunoregulators and potential therapeutic targets—an updated view

W Schulte, J Bernhagen, R Bucala - Mediators of inflammation, 2013 - Wiley Online Library
Sepsis and septic shock are among the leading causes of death in intensive care units
worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the …

Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding

KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

[HTML][HTML] Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony

G Monneret, F Venet, A Pachot, A Lepape - Molecular medicine, 2008 - Springer
Septic syndromes represent a major although largely underrecognized healthcare problem
worldwide, accounting for thousands of deaths every year. It is now agreed that sepsis …

Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with …

Y Heper, EH Akalın, R Mıstık, S Akgöz, O Töre… - European Journal of …, 2006 - Springer
The diagnostic value of procalcitonin, C-reactive protein, tumor necrosis factor-alpha, and
interleukin-10 levels in differentiating sepsis from severe sepsis and the prognostic value of …

Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells

PV Jeurink, CL Noguera, HFJ Savelkoul… - International …, 2008 - Elsevier
Immunomodulation by fungal compounds can be determined by the capacity of the
compounds to influence the cytokine production by human peripheral blood mononuclear …

[HTML][HTML] PMMA-based continuous hemofiltration modulated complement activation and renal dysfunction in LPS-induced acute kidney injury

A Stasi, R Franzin, C Divella, F Sallustio… - Frontiers in …, 2021 - frontiersin.org
Sepsis-induced acute kidney injury (AKI) is a frequent complication in critically ill patients,
refractory to conventional treatments. Aberrant activation of innate immune system may …

Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility

SA Stanilova, LD Miteva, ZT Karakolev… - Intensive care …, 2006 - Springer
Objective To investigate the-1082 (A/G) polymorphism in the promoter of the IL-10 gene in
terms of IL-10 production from stimulated peripheral blood mononuclear cells (PBMC) and to …

[HTML][HTML] Soluble triggering receptor expressed on myeloid cells 1 as an anti-inflammatory mediator in sepsis

EJ Giamarellos-Bourboulis, S Zakynthinos… - Intensive care …, 2006 - Springer
Objective To define the significance of soluble triggering receptor expressed on myeloid
cells 1 (sTREM-1) in the septic cascade by comparing its kinetics to those of other …

Evaluation of biomarkers from peritoneal fluid as predictors of severity for abdominal sepsis patients following emergency laparotomy

J Zhao, T Zhang, Z Deng, X Han, T Ma… - Journal of Inflammation …, 2023 - Taylor & Francis
Purpose Intra-abdominal infection is considered the second most common cause of sepsis
and results in localized or diffused inflammation of the peritoneum. The main treatment for …