Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population.
Treatment of OP poisoning is an ongoing challenge and burden for medical services …

Abstract The Cold War period is characterized by the infighting between the Western
countries and the USSR in diverse areas. One of such fields was development of the …

Obviously, delivery of the medications to the brain is more difficult than other tissues due to
the existence of a strong obstacle, which is called blood-brain barrier (BBB). Because of the …

Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Novichok is the name given to the group of nerve agents created stealthily in the later
phases of the Cold War by the Soviet Union. Constitute the fourth generation of chemical …

Acetylcholinesterase (AChE), a key enzyme in the central and peripheral nervous systems,
is the principal target of organophosphorus nerve agents. Quaternary oximes can …

Poisoning and overdose are very important aspects in medicine and toxicology. Chemical
weapons pose a threat to civilians, and emergency medicine principles must be followed …

Recent years have seen an increasing number of incidence, in which organophosphate
nerve agents (OPNAs) have been used against civilians with devastating outcomes. Current …

Acetylcholinesterase (AChE) plays a vital role in nerve conduction through rapidly
hydrolyzing the neurotransmitter acetylcholine (ACh) and is correlated with Alzheimer's …

The risk of the use of toxic chemicals for unlawful acts has been a matter of concern for
different governments and multilateral agencies. The Organisation for the Prohibition of …