The many facets of erythropoietin physiologic and metabolic response

S Suresh, PK Rajvanshi, CT Noguchi - Frontiers in physiology, 2020 - frontiersin.org
In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Erythropoietin in bone–controversies and consensus

S Hiram-Bab, D Neumann, Y Gabet - Cytokine, 2017 - Elsevier
Erythropoietin (Epo) is the main hormone that regulates the production of red blood cells
(hematopoiesis), by stimulating their progenitors. Beyond this vital function, several …

Erythropoietin directly stimulates osteoclast precursors and induces bone loss

S Hiram‐Bab, T Liron, N Deshet‐Unger… - The FASEB …, 2015 - Wiley Online Library
Erythropoietin (EPO) primarily regulates red blood cell formation, and EPO serum levels are
increased on hypoxic stress (eg, anemia and altitude). In addition to anemia, recent …

Erythropoietin promotes bone formation through EphrinB2/EphB4 signaling

C Li, C Shi, J Kim, Y Chen, S Ni… - Journal of dental …, 2015 - journals.sagepub.com
Recent studies have demonstrated that erythropoietin (EPO) has extensive
nonhematopoietic biological functions. However, little is known about how EPO regulates …

Biomimetic UHMWPE/HA scaffolds with rhBMP-2 and erythropoietin for reconstructive surgery

F Senatov, G Amanbek, P Orlova, M Bartov… - Materials Science and …, 2020 - Elsevier
A promising direction for the replacement of expanded bone defects is the development of
bioimplants based on synthetic biocompatible materials impregnated with growth factors that …

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss

M Rauner, M Murray, S Thiele, D Watts, D Neumann… - Bone Research, 2021 - nature.com
High erythropoietin (Epo) levels are detrimental to bone health in adult organisms. Adult
mice receiving high doses of Epo lose bone mass due to suppressed bone formation and …

Investigation of cell‐free poly lactic acid/nanoclay scaffolds prepared via thermally induced phase separation technique containing hydroxyapatite nanocarriers of …

M Salehi, F Bastami, M Rezai Rad… - Polymers for …, 2021 - Wiley Online Library
The use of cell‐free scaffolds containing bioactive molecules having a controlled released
pattern has been proposed as a promising approach in field of tissue engineering. This …

Effects of erythropoietin on osteoblast in the tooth extraction socket in mice periodontitis model

JE Bae, SM Hwang, YP Aryal, TY Kim, WJ Sohn… - Frontiers in …, 2022 - frontiersin.org
Periodontitis is an excessive inflammatory event in tooth-supporting tissues and can cause
tooth loss. We used erythropoietin (EPO), which has been reported to play an important role …

High plasma erythropoietin predicts incident fractures in elderly men with normal renal function: the MrOS Sweden Cohort

HL Kristjansdottir, C Lewerin, UH Lerner… - Journal of Bone and …, 2020 - academic.oup.com
Preclinical studies on the role of erythropoietin (EPO) in bone metabolism are contradictory.
Regeneration models indicate an anabolic effect on bone healing, whereas models on …

Erythropoietin enhances bone repair effects via the hypoxia-inducible factor signal pathway in glucocorticoid-induced osteonecrosis of the femoral head

D Li, Q Hu, G Tan, X Xie, Z Yang, P Kang - The American Journal of the …, 2018 - Elsevier
Background This study aimed to determine whether erythropoietin could repair
glucocorticoid-induced osteonecrosis of the femoral head after the systemic or local …