There is substantial interest in the therapeutic potential of cannabidiol (CBD), a
nonpsychoactive cannabinoid found in plants of the genus Cannabis. The goal of the current …

Alcohol use disorder represents a significant human health problem that leads to substantial
loss of human life and financial cost to society. Currently available treatment options do not …

Ethanol-induced behavioral sensitization (EBS) was first described in 1980, approximately
10 years after the phenomenon was described for psychostimulants. Ethanol acts on γ …

The endocannabinoid system plays a pivotal role in the regulation of ethanol reinforcing and
motivational actions. The pharmacological manipulation of cannabinoid CB1 receptor (CB 1 …

Previous research in rodents suggests that the long‐term neurobehavioral disturbances
induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system …

Cumulative evidence has pointed out cannabinoid CB2 receptors (CB2r) as a potential
therapeutic key target for treating alcohol use disorder (AUD). This review provides the most …

The motivational circuit activated by ethanol leads to behavioral changes that recruit the
endocannabinoid system (ECS). Case reports and observational studies suggest that the …

Ethanol can induce acute stimulant responses in animals and human beings. Moreover,
repeated exposure to ethanol may produce increased sensitivity to its acute locomotor …

Contextual memory plays an important role in development and maintenance of drug
addiction. However, little is known about of the role contextual memory in the emergence of …

Chronic drug exposure and drug withdrawal induce expressive neuronal plasticity which
could be considered as both functional and pathological responses. It is well established …