The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

Protective immunity against pathogens or cancer is mediated by the activation and clonal
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the
molecular and genetic bases of such sex differences are ill-defined and presumptively …

A dynamic epigenome is critical for appropriate gene expression in development and
health,,,–. Central to this is the intricate process of transcription,,,,–, which integrates cellular …

Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

The aging process worsens the human body functions at multiple levels, thus causing its
gradual decrease to resist stress, damage, and disease. Besides changes in gene …