Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

Muscular dystrophies are a heterogeneous group of inherited disorders that share similar
clinical features and dystrophic changes on muscle biopsy. An improved understanding of …

Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a
key intracellular mediator of a variety of metabolically relevant hormones and cytokines …

Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …

Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500
boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of …

Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to
primary abnormalities in one of the largest genes in the human genome, the DMD gene …

Mechanical unloading induces muscle atrophy and bone loss; however, the time course and
interdependence of these effects is not well defined. We subjected 4‐month‐old C57BL/6J …

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by
mutations to the dystrophin gene, resulting in deficiency of dystrophin protein, loss of …

We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-
inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa …