Phenylketonuria is the most prevalent disorder caused by an inborn error in aminoacid
metabolism. It results from mutations in the phenylalanine hydroxylase gene. Phenotypes …

Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism caused by a
deficiency in the hepatic enzyme phenylalanine hydroxylase (PAH). If left untreated, the …

Phenylketonuria (PKU) is a recessive disorder of phenylalanine metabolism due to
mutations in the gene for phenylalanine hydroxylase (PAH). Reduced PAH activity results in …

Five models of attention deficit/hyperactivity disorder (ADHD) are reviewed. It is proposed
that the cognitive-energetic model provides a reasonably comprehensive account of ADHD …

Blood phenylalanine (Phe) levels provide a practical and reliable method for the diagnosis
and monitoring of metabolic status in patients with phenylketonuria (PKU). To assess the …

Over 20 years have elapsed since aspartame was approved by regulatory agencies as a
sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was …

In untreated phenylketonuria (PKU), deficiency of phenylalanine hydroxylase (PAH) results
in elevated blood phenylalanine (Phe) concentrations and severe mental retardation …

Early-treated phenylketonuria (PKU) is associated with a range of neuropsychological
impairments. Proposed mechanisms for these impairments include dopamine depletion and …

BACKGROUND: The National Institute of Health (NIH) published a Consensus Statement on
the screening and management of Phenylketonuria (PKU) in 2000. The panel involved in …

1. Abstract Background Current concepts of Attention-Deficit/Hyperactivity Disorder (ADHD)
emphasize the role of higher-order cognitive functions and reinforcement processes …