Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

We present a review of the characterization of healthy brain aging using MRI with an
emphasis on morphology, lesions, and quantitative MR parameters. A scope review found …

All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

High-resolution phase—contrast magnetic resonance imaging can now assess flow in
proximal and distal cerebral arteries. The aim of this study was to describe how total cerebral …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Coupled systems of in vitro microfabricated organs-on-a-chip containing small populations
of human cells are being developed to address the formidable pharmacological and …

Energy use limits the information processing power of the brain. However, apart from the
ATP used to power electrical signalling, a significant fraction of the brain's energy …

Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …

A widely accepted dogma is that about 15–20% of cardiac output is received by the brain in
healthy adults under resting conditions. However, it is unclear if the distribution of cardiac …

Aging is a modern concept: human life expectancy has more than doubled in less than 150
yr in Western countries. Longer life span, however, reveals age-related diseases, including …