The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …
[HTML][HTML] Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases
DW Dekens, ULM Eisel, L Gouweleeuw… - Ageing research …, 2021 - Elsevier
Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
[HTML][HTML] Lipocalin 2: novel component of proinflammatory signaling in Alzheimer's disease
Alzheimer's disease (AD) is associated with an altered immune response, resulting in
chronic increased inflammatory cytokine production with a prominent role of TNF-α. TNF-α …
chronic increased inflammatory cytokine production with a prominent role of TNF-α. TNF-α …
Diverse functional roles of lipocalin-2 in the central nervous system
Abstract Lipocalin-2 (LCN2) is an acute phase protein with multiple functions that has
garnered a great deal of interest over the last decade. However, its precise role in the …
garnered a great deal of interest over the last decade. However, its precise role in the …
Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes
In this study, we determined if eicosapentaenoic acid (EPA) promotes beneficial metabolic
activities of subcutaneous adipocytes. Stromal-vascular (SV) cells were isolated from …
activities of subcutaneous adipocytes. Stromal-vascular (SV) cells were isolated from …
Lipocalin-2 inhibits autophagy and induces insulin resistance in H9c2 cells
Abstract Lipocalin-2 (Lcn2; also known as neutrophil gelatinase associated lipocalin, NGAL)
levels are increased in obesity and diabetes and associate with insulin resistance …
levels are increased in obesity and diabetes and associate with insulin resistance …
miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation
H Wang, Y Xu, M Jin, H Li, S Li - International Immunopharmacology, 2021 - Elsevier
Psoriasis is a chronic and relapsing disorder with considerable negative effects on patients'
quality of life. The finer details associated with the molecular mechanism of psoriasis and its …
quality of life. The finer details associated with the molecular mechanism of psoriasis and its …
Interleukin (IL)-22 from IL-20 subfamily of cytokines induces colonic epithelial cell proliferation predominantly through ERK1/2 pathway
The interleukin (IL)-20 subfamily of cytokines consists of IL-19, IL-20, IL-22, IL-24, and IL-26,
and the expression of IL-20, IL-22, and IL-24 is reported to be higher in the colon of patients …
and the expression of IL-20, IL-22, and IL-24 is reported to be higher in the colon of patients …
Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy
Y Ding, H Gao, L Zhao, X Wang, M Zheng - PloS one, 2015 - journals.plos.org
Mitofusin2 (Mfn2), a mitochondrial outer membrane protein serving primarily as a
mitochondrial fusion protein, has multiple functions in regulating cell biological processes …
mitochondrial fusion protein, has multiple functions in regulating cell biological processes …