Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

The cerebrospinal fluid in multiple sclerosis

F Deisenhammer, H Zetterberg, B Fitzner… - Frontiers in …, 2019 - frontiersin.org
Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

OG Thomas, M Bronge, K Tengvall, B Akpinar… - Science …, 2023 - science.org
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which
Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between …

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

M Lombardi, R Parolisi, F Scaroni, E Bonfanti… - Acta …, 2019 - Springer
Microglia are highly plastic immune cells which exist in a continuum of activation states. By
shaping the function of oligodendrocyte precursor cells (OPCs), the brain cells which …

Full spectrum of vitamin D immunomodulation in multiple sclerosis: Mechanisms and therapeutic implications

M Galoppin, S Kari, S Soldati, A Pal… - Brain …, 2022 - academic.oup.com
Vitamin D deficiency has been associated with the risk of multiple sclerosis, disease activity
and progression. Results from in vitro experiments, animal models and analysis of human …

Myelin oligodendrocyte glycoprotein-immunoglobulin G in the CSF: clinical implication of testing and association with disability

YN Kwon, B Kim, JS Kim, H Mo, K Choi… - Neurology …, 2021 - AAN Enterprises
Background and Objective To investigate the clinical relevance of CSF myelin
oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) testing in a large multicenter …

Cumulative roles for Epstein-Barr virus, human endogenous retroviruses, and human herpes virus-6 in driving an inflammatory cascade underlying MS pathogenesis

UC Meier, RC Cipian, A Karimi, R Ramasamy… - Frontiers in …, 2021 - frontiersin.org
Roles for viral infections and aberrant immune responses in driving localized
neuroinflammation and neurodegeneration in multiple sclerosis (MS) are the focus of …

Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis

AO Dulamea - Multiple Sclerosis: Bench to Bedside: Global …, 2017 - Springer
Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) during
development and throughout adulthood. They result from a complex and well controlled …

Proteomics in multiple sclerosis: the perspective of the clinician

D Sandi, Z Kokas, T Biernacki, K Bencsik… - International Journal of …, 2022 - mdpi.com
Multiple sclerosis (MS) is the inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS) that affects approximately 2.8 million people worldwide. In …

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model

NR Jog, MT McClain, LD Heinlen, T Gross… - Journal of …, 2020 - Elsevier
Multiple sclerosis (MS) is an autoimmune demyelinating disease with progressive
neurodegeneration and complex etiology likely involving genetic and environmental factors …