Abstract Background Systematic Reviews (SRs) of experimental animal studies are not yet
common practice, but awareness of the merits of conducting such SRs is steadily increasing …

The vast majority of drugs entering human trials fail. This problem (called “attrition”) is widely
recognized as a public health crisis, and has been discussed openly for the last two …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Animal research plays an important role in the pre-clinical phase of clinical trials. In animal
studies, the power analysis approach to sample size calculation is recommended …

Public acceptance of the use of animals in biomedical research is conditional on it
producing benefits for humans. Pandora Pound and Michael Bracken argue that the benefits …

There is growing concern that poor experimental design and lack of transparent reporting
contribute to the frequent failure of pre-clinical animal studies to translate into treatments for …

Neuropathic pain remains an area of considerable unmet clinical need. Research based on
preclinical animal models has failed to deliver truly novel treatment options, questioning the …

Rationale: Methodological sources of bias and suboptimal reporting contribute to
irreproducibility in preclinical science and may negatively affect research translation …

Intermittent fasting (IF) and high intensity interval training (HIIT) are effective lifestyle
interventions for improving body composition and overall health. However, the long-term …