The principal cell of the kidney collecting duct is one of the most highly regulated epithelial
cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate …

Nitric oxide (NO) plays an important role in various physiological processes in the kidney. In
vivo experiments first suggested that the natriuretic and diuretic effects caused by NO may …

Hypertension is a major public health problem of largely unknown cause. Here, we identify
two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

The cellular distributions of the kidney form of the erythrocyte band 3 chloride/bicarbonate
exchanger and the kidney vacuolar H+-transporting ATPase were examined in rat kidney …

Mammalian cell membranes harbor several types of chloride channels, chloride-cation
symporters/cotransporters, and several classes of anion exchangers/antiporters. These …

Mutations in the WNK4 gene cause pseudohypoaldosteronism type II (PHAII), an autosomal-
dominant disorder of hyperkalemia and hypertension. The target molecules of this putative …

Slc26a4 (Pds, pendrin) is an anion transporter expressed in the apical region of type B and
non-A, non-B intercalated cells of the distal nephron. It is upregulated by aldosterone …

Several transporting epithelia in vertebrates and invertebrates contain cells that are
specialized for proton or bicarbonate secretion. These characteristic 'mitochondria-rich'(MR) …