Review on the diverse biological effects of glabridin
J Zhang, X Wu, B Zhong, Q Liao, X Wang… - Drug Design …, 2023 - Taylor & Francis
Glabridin is a prenylated isoflavan from the roots of Glycyrrhiza glabra Linne and has posed
great impact on the areas of drug development and medicine, due to various biological …
great impact on the areas of drug development and medicine, due to various biological …
Glabridin ameliorates methotrexate-induced liver injury via attenuation of oxidative stress, inflammation, and apoptosis
Despite unprecedented advances in modern medicine, no safe and effective drug is
available to date for oral administration to combat drug-induced liver injury, which is a vital …
available to date for oral administration to combat drug-induced liver injury, which is a vital …
Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region
Biosynthesis of bisaryl preanthraquinone antibiotics by various microorganisms differs in
monomeric subunits as well as their dimerization positions leading to different …
monomeric subunits as well as their dimerization positions leading to different …
Molecular mechanism for the involvement of CYP2E1/NF-κB axis in bedaquiline-induced hepatotoxicity
Bedaquiline (BDQ) is a new class of anti-tubercular (anti-TB) drugs and is currently reserved
for multiple drug resistance (MDR-TB). However, after receiving fast-track approval, its …
for multiple drug resistance (MDR-TB). However, after receiving fast-track approval, its …
Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using In Silico, In Vitro, and In Vivo Approaches
Myricetin, a bioflavonoid, is widely used as functional food/complementary medicine and
has promising multifaceted pharmacological actions against therapeutically validated …
has promising multifaceted pharmacological actions against therapeutically validated …
Rottlerin renders a selective and highly potent CYP2C8 inhibition to impede EET formation for implication in cancer therapy
CYP2C8 is a crucial CYP isoform responsible for the metabolism of xenobiotics and
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …
Glabridin attenuates paracetamol-induced liver injury in mice via CYP2E1-mediated inhibition of oxidative stress
CYP2E1 plays a crucial role in the bio-activation of toxic substances leading to liver
damage. In this context, CYP2E1 converts paracetamol (PCM) to N-acetyl-p-benzoquinone …
damage. In this context, CYP2E1 converts paracetamol (PCM) to N-acetyl-p-benzoquinone …
Identification of Cytochrome P450 2E1 as a Novel Target in Glioma and Development of Its Inhibitor as an Anti‐Tumor Agent
G Hu, Y Fang, H Xu, G Wang, R Yang, F Gao… - Advanced …, 2023 - Wiley Online Library
Glioblastoma (GBM) is a devastating inflammation‐related cancer for which novel
therapeutic targets are urgently required. Previous studies of the authors indicate …
therapeutic targets are urgently required. Previous studies of the authors indicate …
Development of mupirocin-impregnated bacterial cellulosic transdermal patches for the management of skin infection
The present study reports the production of bacterial cellulose (BC) membranes using
Komagataeibacter hansenii for the development of transdermal wound healing patches. BC …
Komagataeibacter hansenii for the development of transdermal wound healing patches. BC …
Glabridin plays dual action to intensify anti-metastatic potential of paclitaxel via impeding CYP2C8 in liver and CYP2J2/EETs in tumor of an orthotopic mouse model of …
A Jamwal, J Chand, A Dash, S Bhatt, S Dhiman… - Chemico-Biological …, 2023 - Elsevier
In spite of unprecedented advances in modern cancer therapy, there is still a dearth of
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …