Progress in deciphering trophoblast cell differentiation during human placentation

Z Xiao, L Yan, X Liang, H Wang - Current opinion in cell biology, 2020 - Elsevier
The maintenance of gestational well-being requires the proper development of both the
embryo and the placenta. Placental trophoblast cells are the major building blocks of the …

A proteomic profile of the healthy human placenta

S Manna, J Scheel, A Noone, CJ McElwain, C Scaife… - Clinical Proteomics, 2023 - Springer
Background The placenta remains one of the least studied organs within the human body.
Yet, placental dysfunction has been associated with various pregnancy complications …

Prediction of HELLP syndrome severity using machine learning algorithms—results from a retrospective study

M Melinte-Popescu, IA Vasilache, D Socolov… - Diagnostics, 2023 - mdpi.com
(1) Background: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is
a rare and life-threatening complication of preeclampsia. The aim of this study was to …

Placental proteome in late-onset of fetal growth restriction

T Gęca, A Stupak, R Nawrot… - Molecular …, 2022 - spandidos-publications.com
Fetal growth restriction (FGR) occurs when the fetus does not reach its genetically
programmed intrauterine potential for growth and affects~ 5–10% of pregnancies. This …

Predictive performance of machine learning-based methods for the prediction of preeclampsia—a prospective study

AS Melinte-Popescu, IA Vasilache, D Socolov… - Journal of Clinical …, 2023 - mdpi.com
(1) Background: Preeclampsia (PE) prediction in the first trimester of pregnancy is a
challenge for clinicians. The aim of this study was to evaluate and compare the predictive …

Human OMICs and computational biology research in Africa: current challenges and prospects

Y Hamdi, L Zass, H Othman, F Radouani… - OMICS: A Journal of …, 2021 - liebertpub.com
Following the publication of the first human genome, OMICs research, including genomics,
transcriptomics, proteomics, and metagenomics, has been on the rise. OMICs studies …

Hydration free energies and solvation structures with molecular density functional theory in the hypernetted chain approximation

S Luukkonen, M Levesque, L Belloni… - The Journal of Chemical …, 2020 - pubs.aip.org
The capability of molecular density functional theory in its lowest, second-order
approximation, equivalent to the hypernetted chain approximation in integral equations, to …

Regulation of epigenetic modifications in the placenta during preeclampsia: PPARγ influences H3K4me3 and H3K9ac in extravillous trophoblast cells

S Meister, L Hahn, S Beyer, C Paul, S Mitter… - International journal of …, 2021 - mdpi.com
The aim of this study was to analyze the expression of peroxisome proliferator-activated
receptor γ (PPARγ) and retinoid X receptor α (RxRα), a binding heterodimer playing a …

Accurate prediction of hydration free energies and solvation structures using molecular density functional theory with a simple bridge functional

D Borgis, S Luukkonen, L Belloni… - The Journal of Chemical …, 2021 - pubs.aip.org
This paper assesses the ability of molecular density functional theory to predict efficiently
and accurately the hydration free energies of molecular solutes and the surrounding …

Assessment of placental extracellular vesicles-associated Fas ligand and TNF-related apoptosis-inducing ligand in pregnancies complicated by early and late onset …

P Ayala-Ramírez, C Machuca-Acevedo… - Frontiers in …, 2021 - frontiersin.org
Preeclampsia (PE) is a hypertensive disorder that affects 2–8% of pregnancies and is one of
the main causes of fetal, neonatal, and maternal mortality and morbidity worldwide. Although …