Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors
transmitting extracellular signals into cells. Here we show that central components of a …

Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from
a complex series of pathophysiological events that evolve in time and space. In this article …

To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living
organisms–survival factor or ruthless killer. It has long been known that Ca2+ signals govern …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …