Myeloid-derived suppressor cells in hematological malignancies: friends or foes
Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that
are characterized by the ability to suppress immune responses and expand during cancer …
are characterized by the ability to suppress immune responses and expand during cancer …
Prognostic role of myeloid-derived suppressor cells in cancers: a systematic review and meta-analysis
Background Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of
immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies …
immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies …
[HTML][HTML] Combined radiotherapy and anti–PD-L1 antibody synergistically enhances antitumor effect in non–small cell lung cancer
X Gong, X Li, T Jiang, H Xie, Z Zhu, F Zhou… - Journal of Thoracic …, 2017 - Elsevier
Introduction Immune escape frequently occurs and restricts the durability of the antitumor
immune response to radiotherapy. Programmed death 1 (PD-1) and programmed death …
immune response to radiotherapy. Programmed death 1 (PD-1) and programmed death …
Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism
Myeloid-derived suppressor cells (MDSC) are induced under diverse pathologic conditions,
including neoplasia, and suppress innate and adaptive immunity. While the mechanisms by …
including neoplasia, and suppress innate and adaptive immunity. While the mechanisms by …
Tumor microenvironment: a main actor in the metastasis process
D Spano, M Zollo - Clinical & experimental metastasis, 2012 - Springer
Over recent decades, various studies have argued that the metastatic tissue
microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth …
microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth …
Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples
A Kotsakis, M Harasymczuk, B Schilling… - Journal of …, 2012 - Elsevier
Myeloid-derived suppressor cells (MDSC) present in the human peripheral blood, represent
a heterogeneous population of cells with monocytic and granulocytic features. To provide …
a heterogeneous population of cells with monocytic and granulocytic features. To provide …
Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer
A Sawant, J Deshane, J Jules, CM Lee, BA Harris… - Cancer research, 2013 - AACR
Enhanced bone destruction is a hallmark of various carcinomas such as breast cancer,
where osteolytic bone metastasis is associated with increased morbidity and mortality …
where osteolytic bone metastasis is associated with increased morbidity and mortality …
Myeloid-derived suppressor cells as therapeutic target in hematological malignancies
K De Veirman, E Van Valckenborgh, Q Lahmar… - Frontiers in …, 2014 - frontiersin.org
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature
myeloid cells that accumulate during pathological conditions such as cancer and are …
myeloid cells that accumulate during pathological conditions such as cancer and are …
Targeting immune suppression with PDE5 inhibition in end-stage multiple myeloma
KA Noonan, N Ghosh, L Rudraraju, M Bui… - Cancer immunology …, 2014 - AACR
Myeloid-derived suppressor cells (MDSC) play a significant role in tumor-induced immune
suppression. Targeting their function could improve antitumor therapies. Previously, we …
suppression. Targeting their function could improve antitumor therapies. Previously, we …
The tyrosine kinase inhibitors imatinib and dasatinib reduce myeloid suppressor cells and release effector lymphocyte responses
L Christiansson, S Söderlund, S Mangsbo… - Molecular cancer …, 2015 - AACR
Immune escape mechanisms promote tumor progression and are hurdles of cancer
immunotherapy. Removing immunosuppressive cells before treatment can enhance …
immunotherapy. Removing immunosuppressive cells before treatment can enhance …