Cell-free protein synthesis: a promising option for future drug development
SK Dondapati, M Stech, A Zemella, S Kubick - BioDrugs, 2020 - Springer
Proteins are the main source of drug targets and some of them possess therapeutic potential
themselves. Among them, membrane proteins constitute approximately 50% of the major …
themselves. Among them, membrane proteins constitute approximately 50% of the major …
Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes
Control of malaria is an important global health issue and there is still an urgent need for the
development of an effective prophylactic vaccine. Multiple studies have provided strong …
development of an effective prophylactic vaccine. Multiple studies have provided strong …
EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites
P Mesén-Ramírez, B Bergmann, TT Tran, M Garten… - PLoS …, 2019 - journals.plos.org
Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar
membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its …
membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its …
EXP1 is required for organisation of EXP2 in the intraerythrocytic malaria parasite vacuole
T Nessel, JM Beck, S Rayatpisheh… - Cellular …, 2020 - Wiley Online Library
Intraerythrocytic malaria parasites reside within a parasitophorous vacuole membrane
(PVM) that closely overlays the parasite plasma membrane. Although the PVM is the site of …
(PVM) that closely overlays the parasite plasma membrane. Although the PVM is the site of …
A lipocalin mediates unidirectional heme biomineralization in malaria parasites
JM Matz, B Drepper, TB Blum… - Proceedings of the …, 2020 - National Acad Sciences
During blood-stage development, malaria parasites are challenged with the detoxification of
enormous amounts of heme released during the proteolytic catabolism of erythrocytic …
enormous amounts of heme released during the proteolytic catabolism of erythrocytic …
Detection of EXP1-specific CD4+ T cell responses directed against a broad range of epitopes including two promiscuous MHC class II binders during acute …
J Heide, NH Wildner, C Ackermann, M Wittner… - Frontiers in …, 2020 - frontiersin.org
Background: T cells are thought to play a major role in conferring immunity against malaria.
This study aimed to comprehensively define the breadth and specificity of the Plasmodium …
This study aimed to comprehensively define the breadth and specificity of the Plasmodium …
Skeleton binding protein 1 localizes to the Maurer's cleft and interacts with PfHSP70-1 and PfHSP70-x in Plasmodium falciparum gametocyte-infected erythrocytes
A Omoda, K Matsumoto, K Yoshino, M Tachibana… - Parasitology …, 2024 - Elsevier
Plasmodium falciparum accounts for the majority of malaria deaths, due to pathology
provoked by the ability of infected erythrocytes to adhere to vascular endothelium within …
provoked by the ability of infected erythrocytes to adhere to vascular endothelium within …
Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates in electron-dense material before passing through the parasitophorous vacuole membrane
Plasmodium falciparum proteins involved in vascular endothelial cell adherence are
transported to the surface of infected erythrocytes. These proteins are exported through …
transported to the surface of infected erythrocytes. These proteins are exported through …
A crucial role for the C‐terminal domain of exported protein 1 during the mosquito and hepatic stages of the Plasmodium berghei life cycle
K Wolanin, D Fontinha, M Sanches‐Vaz… - Cellular …, 2019 - Wiley Online Library
Intracellular Plasmodium parasites develop inside a parasitophorous vacuole (PV), a
specialised compartment enclosed by a membrane (PVM) that contains proteins of both host …
specialised compartment enclosed by a membrane (PVM) that contains proteins of both host …
Timing of dense granule biogenesis in asexual malaria parasites
T Vallintine, C van Ooij - Microbiology, 2023 - microbiologyresearch.org
Malaria is an important infectious disease that continues to claim hundreds of thousands of
lives annually. The disease is caused by infection of host erythrocytes by apicomplexan …
lives annually. The disease is caused by infection of host erythrocytes by apicomplexan …