Changes in the properties and postsynaptic abundance of AMPA-type glutamate receptors
(AMPARs) are major mechanisms underlying various forms of synaptic plasticity, including …

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a
cellular correlate for learning and memory,. Early LTP (less than 1 h) had initially been …

Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes
whose functional characteristics vary across the different brain regions and change during …

Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …

The Ca 2+/Calmodulin (CaM)-dependent protein kinase II (CaMKII) is activated by Ca
2+/CaM, but becomes partially autonomous (Ca 2+-independent) upon autophosphorylation …

Even in healthy individuals there is an inexorable agerelated decline in cognitive function.
This is due, in large part, to reduced synaptic plasticity caused by changes in the molecular …

One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …