Neurofilament light chain as neuronal injury marker–what is needed to facilitate implementation in clinical laboratory practice?

B Arslan, H Zetterberg - Clinical Chemistry and Laboratory Medicine …, 2023 - degruyter.com
Neurobiomarkers have attracted significant attention over the last ten years. One promising
biomarker is the neurofilament light chain protein (NfL). Since the introduction of …

Introducing neurofilament light chain measure in psychiatry: current evidence, opportunities, and pitfalls

F Bavato, C Barro, LK Schnider, J Simrén… - Molecular …, 2024 - nature.com
The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …

Plasma neurofilament light chain as a biomarker of Alzheimer's disease in subjective cognitive decline and mild cognitive impairment

G Giacomucci, S Mazzeo, S Bagnoli, A Ingannato… - Journal of …, 2022 - Springer
Abstract Introduction Neurofilament light chain (NfL) is becoming increasingly notable in
neurological diseases including AD, and it has been suggested as a new peripherical …

Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders

D Eratne, M Kang, C Malpas… - Australian & New …, 2024 - journals.sagepub.com
Objective: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show
promise to improve diagnosis of neurodegenerative disorders and distinguish …

[HTML][HTML] Biomarkers in frontotemporal dementia: Current landscape and future directions

A Gifford, N Praschan, A Newhouse… - Biomarkers in …, 2023 - Elsevier
Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …

Recent research advances in young-onset dementia

SM Loi, Y Pijnenburg, D Velakoulis - Current opinion in psychiatry, 2023 - journals.lww.com
Recent research advances in young-onset dementia : Current Opinion in Psychiatry Recent
research advances in young-onset dementia : Current Opinion in Psychiatry Log in or …

Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders

MJY Kang, D Eratne, H Dobson, CB Malpas… - Acta …, 2024 - cambridge.org
Objective: People with neuropsychiatric symptoms often experience delay in accurate
diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in …

The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's …

S Das, MPE van Engelen, J Goossens… - Alzheimer's Research & …, 2024 - Springer
Background Lack of early molecular biomarkers in sporadic behavioral variants of
frontotemporal dementia (bvFTD) and its clinical overlap with primary psychiatric disorders …

Cerebrospinal fluid neurofilament light chain differentiates behavioural variant frontotemporal dementia progressors from non-progressors

D Eratne, M Keem, C Lewis, M Kang… - Journal of the …, 2022 - Elsevier
Background: Distinguishing behavioural variant frontotemporal dementia (bvFTD) from non-
neurodegenerative 'non-progressor'mimics of frontal lobe dysfunction, can be one of the …

Comparison of CSF and plasma NfL and pNfH for Alzheimer's disease diagnosis: a memory clinic study

A Vrillon, NJ Ashton, TK Karikari, K Götze, E Cognat… - Journal of …, 2024 - Springer
Plasma neurofilament light chain (NfL) is a promising biomarker of axonal damage for the
diagnosis of neurodegenerative diseases. Phosphorylated neurofilament heavy chain …