[HTML][HTML] The therapeutic potential of second and third generation CB1R antagonists
Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages
M Whiteman, L Li, P Rose, CH Tan… - Antioxidants & redox …, 2010 - liebertpub.com
The role of hydrogen sulfide (H2S) in inflammation is controversial, with both pro-and
antiinflammatory effects documented. Many studies have used simple sulfide salts as the …
antiinflammatory effects documented. Many studies have used simple sulfide salts as the …
Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1, 2‐dimethylhydrazine‐induced rat …
S Umesalma, G Sudhandiran - Basic & clinical pharmacology & …, 2010 - Wiley Online Library
Dietary polyphenols have been found to possess preventive and therapeutic potential
against several types of cancers. We investigated the effect of ellagic acid on colon cancer …
against several types of cancers. We investigated the effect of ellagic acid on colon cancer …
Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and …
AD Kandhare, SL Bodhankar, V Mohan… - Chemico-biological …, 2015 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial
disease with limited therapeutic options. Glycosides based standardized fenugreek seed …
disease with limited therapeutic options. Glycosides based standardized fenugreek seed …
HSP47: a therapeutic target in pulmonary fibrosis
N Sakamoto, D Okuno, T Tokito, H Yura, T Kido… - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …
Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
S Kalayarasan, PN Prabhu, N Sriram… - European journal of …, 2009 - Elsevier
The protective role of diallyl sulfide (DAS) in attenuating gentamicin-induced nephrotoxicity
has been reported earlier. However, the mechanism of induction of antioxidants by DAS in …
has been reported earlier. However, the mechanism of induction of antioxidants by DAS in …
Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 …
The mechanism involved in the enhancement of antioxidant activities and resolved
inflammation after epigallocatechin-3-gallate (EGCG) treatment during bleomycin-induced …
inflammation after epigallocatechin-3-gallate (EGCG) treatment during bleomycin-induced …
[HTML][HTML] Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB …
Z Zhou, AD Kandhare, AA Kandhare… - EXCLI …, 2019 - ncbi.nlm.nih.gov
Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic
pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has …
pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has …
Oxidative stress and lung fibrosis: towards an adverse outcome pathway
P Makena, T Kikalova, GL Prasad… - International Journal of …, 2023 - mdpi.com
Lung fibrosis is a progressive fatal disease in which deregulated wound healing of lung
epithelial cells drives progressive fibrotic changes. Persistent lung injury due to oxidative …
epithelial cells drives progressive fibrotic changes. Persistent lung injury due to oxidative …
Diallyl sulfide: potential use in novel therapeutic interventions in alcohol, drugs, and disease mediated cellular toxicity by targeting cytochrome P450 2E1
Diallyl sulfide (DAS) and other organosulfur compounds are chief constituents of garlic.
These compounds have many health benefits, as they are very efficient in detoxifying natural …
These compounds have many health benefits, as they are very efficient in detoxifying natural …