[HTML][HTML] The therapeutic potential of second and third generation CB1R antagonists

R Cinar, MR Iyer, G Kunos - Pharmacology & therapeutics, 2020 - Elsevier
Endocannabinoids acting via CB 1 receptors (CB 1 R) play a critical role in regulating
energy homeostasis, which was the rationale for the pharmaceutical development of CB 1 R …

The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages

M Whiteman, L Li, P Rose, CH Tan… - Antioxidants & redox …, 2010 - liebertpub.com
The role of hydrogen sulfide (H2S) in inflammation is controversial, with both pro-and
antiinflammatory effects documented. Many studies have used simple sulfide salts as the …

Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF‐κB, iNOS, COX‐2, TNF‐α, and IL‐6 in 1, 2‐dimethylhydrazine‐induced rat …

S Umesalma, G Sudhandiran - Basic & clinical pharmacology & …, 2010 - Wiley Online Library
Dietary polyphenols have been found to possess preventive and therapeutic potential
against several types of cancers. We investigated the effect of ellagic acid on colon cancer …

Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: decisive role of Bax, Nrf2, NF-κB, Muc5ac, TNF-α and …

AD Kandhare, SL Bodhankar, V Mohan… - Chemico-biological …, 2015 - Elsevier
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive multifactorial
disease with limited therapeutic options. Glycosides based standardized fenugreek seed …

HSP47: a therapeutic target in pulmonary fibrosis

N Sakamoto, D Okuno, T Tokito, H Yura, T Kido… - Biomedicines, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by a progressive
decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) …

Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats

S Kalayarasan, PN Prabhu, N Sriram… - European journal of …, 2009 - Elsevier
The protective role of diallyl sulfide (DAS) in attenuating gentamicin-induced nephrotoxicity
has been reported earlier. However, the mechanism of induction of antioxidants by DAS in …

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 …

N Sriram, S Kalayarasan, G Sudhandiran - Pulmonary pharmacology & …, 2009 - Elsevier
The mechanism involved in the enhancement of antioxidant activities and resolved
inflammation after epigallocatechin-3-gallate (EGCG) treatment during bleomycin-induced …

[HTML][HTML] Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB …

Z Zhou, AD Kandhare, AA Kandhare… - EXCLI …, 2019 - ncbi.nlm.nih.gov
Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic
pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has …

Oxidative stress and lung fibrosis: towards an adverse outcome pathway

P Makena, T Kikalova, GL Prasad… - International Journal of …, 2023 - mdpi.com
Lung fibrosis is a progressive fatal disease in which deregulated wound healing of lung
epithelial cells drives progressive fibrotic changes. Persistent lung injury due to oxidative …

Diallyl sulfide: potential use in novel therapeutic interventions in alcohol, drugs, and disease mediated cellular toxicity by targeting cytochrome P450 2E1

PSS Rao, NM Midde, DD Miller… - Current drug …, 2015 - ingentaconnect.com
Diallyl sulfide (DAS) and other organosulfur compounds are chief constituents of garlic.
These compounds have many health benefits, as they are very efficient in detoxifying natural …