In the past decade, the view on genomic structural variation (SV) has been changed
completely. SVs, previously considered rare events, are now recognized as the largest …

Abstract Background The Framingham Heart Study (FHS), founded in 1948 to examine the
epidemiology of cardiovascular disease, is among the most comprehensively characterized …

Objectives—We have investigated the functional significance of conserved sequences
within the 9p21. 3 risk locus for coronary artery disease (CAD) and determined the …

Abstract The Holocene (beginning around 12,000 years ago) encompassed some of the
most significant changes in human evolution, with far-reaching consequences for the …

Single nucleotide polymorphisms (SNPs) are common DNA sequence variations that occur
at single bases within the genome. SNPs have been instrumental in elucidating the genetic …

Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …

Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …

Background Alterations in gene expression in peripheral blood cells have been shown to be
sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive blood …

Background and Purpose: Stroke is a complex disease with multiple genetic and
environmental risk factors. Blacks endure a nearly 2-fold greater risk of stroke and are 2× to …

Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We
have previously identified genetic linkage to familial CAD in the genomic region of NPY. We …