Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
Refactoring transcription factors for metabolic engineering
C Deng, Y Wu, X Lv, J Li, Y Liu, G Du, J Chen… - Biotechnology …, 2022 - Elsevier
Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …
regulation systems composed of transcription factors have been widely used in metabolic …
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization
E Oberbeckmann, K Quililan, P Cramer… - Nature Genetics, 2024 - nature.com
Eukaryotic genomes are organized into chromatin domains. The molecular mechanisms
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
driving the formation of these domains are difficult to dissect in vivo and remain poorly …
Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries
Abstract Topologically Associating Domains (TADs) separate vertebrate genomes into
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
insulated regulatory neighborhoods that focus genome-associated processes. TADs are …
ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells of origin
R Sadeh, I Sharkia, G Fialkoff, A Rahat, J Gutin… - Nature …, 2021 - nature.com
Cell-free DNA (cfDNA) in human plasma provides access to molecular information about the
pathological processes in the organs or tumors from which it originates. These DNA …
pathological processes in the organs or tumors from which it originates. These DNA …
Single-cell omics in ageing: a young and growing field
Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …
The study of ageing at the molecular level is complicated by varying decay characteristics …
Epigenome regulation by dynamic nucleosome unwrapping
S Brahma, S Henikoff - Trends in biochemical sciences, 2020 - cell.com
Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …
transcription factors (TFs) to their sites in a chromatin landscape dominated by …
Genome information processing by the INO80 chromatin remodeler positions nucleosomes
E Oberbeckmann, N Krietenstein, V Niebauer… - Nature …, 2021 - nature.com
The fundamental molecular determinants by which ATP-dependent chromatin remodelers
organize nucleosomes across eukaryotic genomes remain largely elusive. Here, chromatin …
organize nucleosomes across eukaryotic genomes remain largely elusive. Here, chromatin …
Building transcription factor binding site models to understand gene regulation in plants
Transcription factors (TFs) are key cellular components that control gene expression. They
recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to …
recognize specific DNA sequences, the TF binding sites (TFBSs), and thus are targeted to …
Single-cell technologies in multiple myeloma: new insights into disease pathogenesis and translational implications
M Chen, J Jiang, J Hou - Biomarker Research, 2023 - Springer
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation
of plasma cells. Although therapeutic advances have been made to improve clinical …
of plasma cells. Although therapeutic advances have been made to improve clinical …