Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth …

The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis,
detoxification, and numerous other necessary functions. Various acute, chronic, and …

Genetic regulators and environmental stimuli modulate T cell activation in autoimmunity and
cancer. The enzyme co-factor tetrahydrobiopterin (BH4) is involved in the production of …

For more than 100 years, the human amniotic membrane (hAM) has been used in multiple
tissue regeneration applications. The hAM consists of cells with stem cell characteristics and …

Developmental toxicity testing urgently requires the implementation of human-relevant new
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …

Osteoarthritis (OA) is one of the most common causes of disability and represents a major
socio-economic burden. Despite intensive research, the molecular mechanisms responsible …

Human amniotic epithelial cells (hAECs), derived from an epithelial cell layer of the human
amniotic membrane, possess embryonic stem-like properties and are known to maintain …

Bladder cancer is one of the most common cancers among men in industrialized countries
and on the global level incidence and mortality rates are increasing. In spite of progress in …

Fetal skin achieves scarless wound repair. Dermal fibroblasts play a central role in
extracellular matrix deposition and scarring outcomes. Both fetal and gingival wound repair …

Reactive oxygen species (ROS) have recently been recognized as important signal
transducers, particularly regulating proliferation and differentiation of cells …