Ceria‐based therapeutic antioxidants for biomedical applications

YG Kim, Y Lee, N Lee, M Soh, D Kim… - Advanced …, 2024 - Wiley Online Library
The growing interest in nanomedicine over the last 20 years has carved out a research field
called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are …

Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

S Zhou, H Cai, X He, Z Tang, S Lu - Coordination Chemistry Reviews, 2024 - Elsevier
Reactive oxygen species (ROS) perform vital functions in numerous life processes and
significantly affect physiological activities in different organ systems in the human body …

Redox homeostasis strategy for inflammatory macrophage reprogramming in rheumatoid arthritis based on ceria oxide nanozyme-complexed biopolymeric micelles

F Zhou, M Li, M Chen, M Chen, X Chen, Z Luo, K Cai… - ACS …, 2023 - ACS Publications
The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by
inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which …

Targeting endogenous reactive oxygen species removal and regulating regenerative microenvironment at annulus fibrosus defects promote tissue repair

F Han, Z Tu, Z Zhu, D Liu, Q Meng, Q Yu, Y Wang… - ACS …, 2023 - ACS Publications
The excessive reactive oxygen species (ROS) level, inflammation, and weak tissue
regeneration ability after annulus fibrosus (AF) injury constitute an unfavorable …

Hydrogel dressing integrating FAK inhibition and ROS scavenging for mechano-chemical treatment of atopic dermatitis

Y Jia, J Hu, K An, Q Zhao, Y Dang, H Liu, Z Wei… - Nature …, 2023 - nature.com
Atopic dermatitis (AD) is a chronic skin disease caused by skin immune dyshomeostasis and
accompanied by severe pruritus. Although oxidative stress and mechanical scratching can …

ROS‐Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve …

D Liu, G Lu, B Shi, H Ni, J Wang, Y Qiu… - Advanced …, 2023 - Wiley Online Library
Although stem cell‐based therapy is recognized as a promising therapeutic strategy for
spinal cord injury (SCI), its efficacy is greatly limited by local reactive oxygen species (ROS) …

Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing

S Zhao, J Ling, N Wang, X Ouyang - Chemical Engineering Journal, 2024 - Elsevier
Diabetic wounds are among the most severe chronic complications in patients with diabetes.
Owing to the detrimental effects of high glucose and high levels of reactive oxygen species …

Hyaluronic acid‐based reactive oxygen species‐responsive multifunctional injectable hydrogel platform accelerating diabetic wound healing

C Shi, Y Zhang, G Wu, Z Zhu, H Zheng… - Advanced …, 2024 - Wiley Online Library
Diabetic wounds are more likely to develop into complex and severe chronic wounds. The
objective of this study is to develop and assess a reactive oxygen species (ROS)‐responsive …

Orally administrated inflamed colon-targeted nanotherapeutics for inflammatory bowel disease treatment by oxidative stress level modulation in colitis

DK Min, YE Kim, MK Kim, SW Choi, N Park, J Kim - ACS nano, 2023 - ACS Publications
Inflammatory bowel disease (IBD) is characterized by an inappropriate and persistent
inflammatory immune response and is often accompanied by excessive reactive oxygen …

Adhesive composite hydrogel patch for sustained transdermal drug delivery to treat atopic dermatitis

YE Kim, HY Jung, N Park, J Kim - Chemistry of Materials, 2023 - ACS Publications
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Continuous
administration of steroids often causes undesired side effects; hence, drug delivery systems …