Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

D Jonigk, C Werlein, T Acker, M Aepfelbacher… - Virchows Archiv, 2022 - Springer
The use of autopsies in medicine has been declining. The COVID-19 pandemic has
documented and rejuvenated the importance of autopsies as a tool of modern medicine. In …

Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry

E Qing, P Li, L Cooper, S Schulz, HM Jäck, L Rong… - Cell reports, 2022 - cell.com
SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in
the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive …

Smoking and vaping alter genes related to mechanisms of SARS-CoV-2 susceptibility and severity: a systematic review and meta-analysis

R Bowsher, TH Marczylo, K Gooch… - European …, 2024 - publications.ersnet.org
Background Evidence for the impact of smoking on coronavirus disease 2019 (COVID-19) is
contradictory, and there is little research on vaping. Here we provide greater clarity on …

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice

AS Ashhurst, MD Johansen, JWC Maxwell… - Nature …, 2022 - nature.com
Current vaccines against SARS-CoV-2 substantially reduce mortality, but protection against
infection is less effective. Enhancing immunity in the respiratory tract, via mucosal …

Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19

A Valenzuela-Fernández… - … in Bioengineering and …, 2022 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the
associated coronavirus disease 2019 (COVID-19), which severely affect the respiratory …

[HTML][HTML] The Interplay between Airway Cilia and Coronavirus Infection, Implications for Prevention and Control of Airway Viral Infections

X Dai, R Xu, N Li - Cells, 2024 - mdpi.com
Coronaviruses (CoVs) are a class of respiratory viruses with the potential to cause severe
respiratory diseases by infecting cells of the upper respiratory tract, bronchial epithelium …

Influence of cell type specific infectivity and tissue composition on SARS-CoV-2 infection dynamics within human airway epithelium

B Raach, N Bundgaard, MJ Haase… - PLOS Computational …, 2023 - journals.plos.org
Human airway epithelium (HAE) represents the primary site of viral infection for SARS-CoV-
2. Comprising different cell populations, a lot of research has been aimed at deciphering the …

3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and …

VMF Amorim, EP Soares, ASA Ferrari, DGS Merighi… - Viruses, 2024 - mdpi.com
Proteases represent common targets in combating infectious diseases, including COVID-19.
The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19 …

Animal models for the study of SARS-CoV-2–induced respiratory disease and pathology

JA Dillard, SA Martinez, JJ Dearing… - Comparative …, 2023 - ingentaconnect.com
Emergence of the betacoronavirus SARS-CoV-2 has resulted in a historic pandemic, with
millions of deaths worldwide. An unprecedented effort has been made by the medical …