Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases.
They mediate the degradation of extracellular particles from endocytosis and of intracellular …

Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …

Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca2+
homoeostasis are common features in many lysosomal storage diseases. Mucolipin …

Transient receptor potential (TRP) channels are a large family of ion channel proteins,
surpassed in number in mammals only by voltage-gated potassium channels. TRP channels …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Necrotic cell death was long regarded as the ultimate consequence of chemical toxicity and
was thought to result from simple cell failure because of toxic interference with vital cell …

Phagocytosis of large extracellular particles such as apoptotic bodies requires delivery of
the intracellular endosomal and lysosomal membranes to form plasmalemmal pseudopods …