More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of
American women of reproductive age. Obesity is associated with many adverse maternal …

A healthy nutritional state is required for all aspects of reproduction and is signaled by the
adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little …

Lifestyle factors, which include the practices we adopt in our daily life, have a significant role
in shaping our overall health. These lifestyle choices are mainly centered on personal …

The prevalence of obesity and overweight are increasing and have become an epidemic
worldwide. Obesity has detrimental influences on all systems, including reproductive health …

Whilst many multiparous women are obese (body mass index O30 kg/m2), obesity has been
associated with impaired fecundity; however, the mechanism which links obesity to reduced …

The aim of this narrative review is to provide current evidence for the interaction between
obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone …

Obesity, particularly the abdominal phenotype, is associated with several reproductive
disturbances. Whereas mechanisms by which obesity affect fertility are complex and still not …

Summary The aetiology of Polycystic Ovary Syndrome (PCOS) is complex and multifactorial.
There is much evidence, however, to suggest that adipose tissue plays an important role in …

It is widely held that mammalian cumulus cell (CC) expansion requires oocyte-paracrine
signalling, however in three of the four species studied to date, CC expansion occurs in the …