Transposable elements are mobile genetic units that exhibit broad diversity in their structure
and transposition mechanisms. Transposable elements occupy a large fraction of many …

Abstract Background 22q11. 2 deletion syndrome (22q11DS), a copy number variation
(CNV) disorder, occurs in approximately 1: 4000 live births due to a heterozygous …

Pluripotency is a unique biological state that allows cells to differentiate into any tissue type.
Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain …

Ataxin-3 (AT3), the disease protein in spinocerebellar ataxia type 3 (SCA3), has been
associated with the ubiquitin–proteasome system and transcriptional regulation. Here we …

We recently cloned a novel human nuclear factor (designated THAP1) from postcapillary
venule endothelial cells (ECs) that contains a DNA-binding THAP domain, shared with …

We have recently described an evolutionarily conserved protein motif, designated the THAP
domain, which defines a previously uncharacterized family of cellular factors (THAP …

The human chromosome 22q11. 2 region is susceptible to rearrangements during meiosis
leading to velo-cardio-facial/DiGeorge/22q11. 2 deletion syndrome (22q11DS) …

The hereditary dystonias comprise a set of diseases defined by a common constellation of
motor deficits. These disorders are most likely associated with different molecular etiologies …

Abstract THAP-family C2CH zinc-coordinating DNA-binding proteins function in diverse
eukaryotic cellular processes, such as transposition, transcriptional repression, stem-cell …

THAP1, the founding member of a previously uncharacterized large family of cellular
proteins (THAP proteins), is a sequence-specific DNA-binding factor that has recently been …