Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than
the disease and are ineffective in up to 30% of patients. There are no treatments for …

Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

Status epilepticus (SE) is the maximal expression of epilepsy with a high morbidity and
mortality. It occurs due to the failure of mechanisms that terminate seizures. Both human and …

Preclinical studies in immature and adult rodents and clinical observations show that
neuroinflammation and oxidative stress are rapid onset phenomena occurring in the brain …

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …

Epilepsy is a common neurological disorder which affects patients physically and mentally
and causes a real burden for the patient, family and society both medically and …

Epilepsy therapy is based on antiseizure drugs that treat the symptom, seizures, rather than
the disease and are ineffective in up to 30% of patients. There are no treatments for …