Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

DNA methylation is a crucial element in the epigenetic regulation of mammalian embryonic
development,,,,. However, its dynamic patterns have not been analysed at the genome scale …

Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …

Background Developmental programming of the embryo is controlled by genetic information
but also dictated by epigenetic information contained in spermatozoa. Lifestyle and …

DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic
development,–. Although the DNA methylome of early human embryos has been analyzed …

Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …

In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and
stably distributed across the genome, with local, cell-type-specific regulation directed by …

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly
accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization …

Transposable elements (TEs) are abundant in the human genome, and some are capable of
generating new insertions through RNA intermediates. In cancer, the disruption of cellular …