A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling

D Hasan, A Shono, CK van Kalken, PJ van der Spek… - Purinergic …, 2022 - Springer
Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

Pharmacological Modulation and (Patho) Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease

C Dienes, ZM Kovács, T Hézső, J Almássy, J Magyar… - Pharmaceuticals, 2021 - mdpi.com
Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein
family and, similarly to TRPM5, is Ca2+ sensitive and permeable for monovalent but not …

Lidocaine suppresses viability and migration of human breast cancer cells: TRPM7 as a target for some breast cancer cell lines

H Liu, JP Dilger, J Lin - Cancers, 2021 - mdpi.com
Simple Summary The local anesthetic lidocaine suppresses some cancer cell lines but the
mechanism is unclear. Melastatin-like transient receptor potential 7 (TRPM7) ion channels …

[HTML][HTML] Medical perspective in testicular ischemia‑reperfusion injury

S Arena, R Iacona, P Antonuccio… - Experimental and …, 2017 - spandidos-publications.com
Testicular torsion or torsion of the spermatic cord is one of the most serious urological
conditions. It causes testicular injury, which potentially leads to male subfertility. The turning …

Transient receptor potential melastatin 7 and their modulators

XY Cheng, SF Li, Y Chen, YJ Zhao, W Hu, C Lu… - European Journal of …, 2022 - Elsevier
TRPM (transient receptor potential melastatin) 7, a member of the TRPM subfamily, is a
nonselective cation channel located on the cell membrane that regulates mammalian cell …

Detrimental or beneficial: the role of TRPM2 in ischemia/reperfusion injury

K Zhan, P Yu, C Liu, J Luo, W Yang - Acta Pharmacologica Sinica, 2016 - nature.com
Abstract Ischemia/reperfusion (I/R) injury is the main cause of tissue damage and
dysfunction. I/R injury is characterized by Ca 2+ overload and production of reactive oxygen …

Nickel (II) and cobalt (II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

L Tabrizi, P McArdle, A Erxleben… - European journal of …, 2015 - Elsevier
Metal complexes of the type [Ni (LC) 2 (X) 2], 1 and 2,[Co (LC) 2 (X) 2], 3 and 4 (LC:
lidocaine, X= dca (dicyanamide), 1 and 3, X= NCS−, 2 and 4) have been synthesized and …

Effects of amlodipine on ischaemia/reperfusion injury in the rat testis

C Dogan, Z Halici, A Topçu, E Cadirci, E Karakus… - Andrologia, 2016 - Wiley Online Library
The aim of this study was to examine the effects of amlodipine (AML) in rat testicular
torsion/detorsion damage. In this study, rats were divided into eight groups:(i) sham;(ii) …

Effects of lidocaine on random skin flap survival in rats

B Cao, L Wang, D Lin, L Cai, W Gao - Dermatologic Surgery, 2015 - journals.lww.com
Effects of Lidocaine on Random Skin Flap Survival in Rats : Dermatologic Surgery Effects of
Lidocaine on Random Skin Flap Survival in Rats : Dermatologic Surgery Log in or Register …

[HTML][HTML] Over-activation of TRPM2 ion channel accelerates blood-spinal cord barrier destruction in diabetes combined with spinal cord injury rat

S Zhang, J Zhao, M Wu, Y Zhou, X Wu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is a devastating neurological disorder that often results in loss of
motor and sensory function. Diabetes facilitates the blood-spinal cord barrier (BSCB) …