Off-label use of medication may be presented in these guidelines if a sufficient level of
evidence shows that it can be considered medically appropriate to a given condition and if …

Cardiac surgery is associated with perioperative blood loss and a high risk of allogeneic
blood transfusion. Patient blood management (PBM) in cardiac surgery contributes to the …

Guidelines Management of severe peri-operative bleeding: Guidelines from the European
Society of Anaesthesiology and Intensive Care

The management of perioperative bleeding involves multiple assessments and strategies to
ensure appropriate patient care. Initially, it is important to identify those patients with an …

Document Reviewers: Moritz WV Wyler von Ballmoos (USA), Mate Petricevic (Croatia), Arie
Pieter Kappetein (Netherlands), Miguel Sousa-Uva (Portugal), Georg Trummer (Germany) …

Experience with tranexamic acid, an indirect fibrinolytic inhibitor, started as soon as it was
released from Shosuke Okamoto's lab in the early 1960s. It was first prescribed to females …

Background: There is a growing concern for microbial resistance as a result of overuse of
antibiotics. Although guidelines have focused on the use of antibiotics for surgery in general …

Background More than 30% of the world's population are anemic with serious medical and
economic consequences. Red blood cell transfusion is the mainstay to correct anemia, but it …

Background Clinical studies investigating topical hemostatic agents have not used
standardized definitions for intraoperative bleeding. The Food and Drug Administration has …

BACKGROUND: Postoperative bleeding remains a frequent complication after
cardiovascular surgery and may contribute to serious morbidity and mortality. Observational …