Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …
[HTML][HTML] Multivalent glycoconjugates as anti-pathogenic agents
A Bernardi, J Jiménez-Barbero, A Casnati… - Chemical Society …, 2013 - pubs.rsc.org
Multivalency plays a major role in biological processes and particularly in the relationship
between pathogenic microorganisms and their host that involves protein–glycan recognition …
between pathogenic microorganisms and their host that involves protein–glycan recognition …
Chemical glycobiology
CR Bertozzi, LL Kiessling - Science, 2001 - science.org
Chemical tools have proven indispensable for studies in glycobiology. Synthetic
oligosaccharides and glycoconjugates provide materials for correlating structure with …
oligosaccharides and glycoconjugates provide materials for correlating structure with …
Glycopolymer probes of signal transduction
LL Kiessling, JC Grim - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …
communication to infection. Revealing glycan roles and the underlying molecular …
[图书][B] Handbook of nanoscience, engineering, and technology
Nanotechnology, science, and engineering spearhead the 21st century revolution that is
leading to fundamental breakthroughs in the way materials, devices, and systems are …
leading to fundamental breakthroughs in the way materials, devices, and systems are …
Pathogen inhibition by multivalent ligand architectures
S Bhatia, LC Camacho, R Haag - Journal of the American …, 2016 - ACS Publications
Interfacial multivalent interactions at pathogen–cell interfaces can be competitively inhibited
by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages …
by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages …
Maximising multivalency effects in protein–carbohydrate interactions
RJ Pieters - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Multivalent carbohydrates are currently produced in many forms ranging from dendrimers,
polymers, micelles, vesicles, nanoparticles to functionalized nanotubes, in order to enhance …
polymers, micelles, vesicles, nanoparticles to functionalized nanotubes, in order to enhance …
Structure, biological functions and applications of the AB5 toxins
AB 5 toxins are important virulence factors for several major bacterial pathogens, including
Bordetella pertussis, Vibrio cholerae, Shigella dysenteriae and at least two distinct …
Bordetella pertussis, Vibrio cholerae, Shigella dysenteriae and at least two distinct …
Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response
H Yamazaki, N Hiramatsu, K Hayakawa… - The Journal of …, 2009 - journals.aai.org
Shiga toxin has the potential to induce expression of inflammation-associated genes,
although the underlying mechanisms are not well understood. We examined the effects of …
although the underlying mechanisms are not well understood. We examined the effects of …
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
AB5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that
corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake …
corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake …