Syntheses and applications of 1, 2, 3-triazole-fused pyrazines and pyridazines

GR Hoffman, AM Schoffstall - Molecules, 2022 - mdpi.com
Pyrazines and pyridazines fused to 1, 2, 3-triazoles comprise a set of heterocycles obtained
through a variety of synthetic routes. Two typical modes of constructing these heterocyclic …

Advances in the synthesis of fused 1, 2, 3-triazoles via a MCR-intramolecular azide-alkyne cycloaddition Approach

J Thomas, W Dehaen, J John - Molecules, 2023 - mdpi.com
The present review narrates several reports which deal with the synthesis of fused 1, 2, 3-
triazole containing scaffolds following a sequential multicomponent reaction (MCR) …

Synthesis and biological evaluation of coumarine-imidazo [1, 2-c][1, 2, 3] triazoles: PEG-400 mediated one-pot reaction under ultrasonic irradiation

R Samala, SK Nukala, R Manchal, VR Nagavelli… - Journal of Molecular …, 2023 - Elsevier
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. To investigate the …

Flavone-1, 2, 3-triazole derivatives as potential α-glucosidase inhibitors: Synthesis, enzyme inhibition, kinetic analysis and molecular docking study

M Dhameja, H Kumar, S Kurella, A Uma, P Gupta - Bioorganic Chemistry, 2022 - Elsevier
Abstract α-Glucosidase inhibitors are considered prime therapeutics in the management of
type-2 diabetes and are preferred due to their localized action ushered by limited side …

Copper-Mediated Intramolecular Interrupted CuAAC Selanylation

WKO Teixeira, DY de Albuquerque… - The Journal of …, 2023 - ACS Publications
We, herein, describe a copper-mediated domino CuAAC intramolecular selanylation for the
synthesis of unprecedented fused benzo [4, 5][1, 3] selenazolo [3, 2-c][1, 2, 3] triazoles from …

Palladium Iodide‐Catalyzed Selective Carbonylative Double Cyclization of 4‐(2‐Aminophenyl)‐3‐yn‐1‐ols to Dihydrofuroquinolinone Derivatives

R Mancuso, A De Salvo, P Russo… - Chinese Journal of …, 2023 - Wiley Online Library
Comprehensive Summary The PdI2/KI‐catalyzed oxidative carbonylation of 4‐(2‐
aminophenyl)‐3‐yn‐1‐ols, bearing two potential nucleophilic groups in suitable position …

Biomass derived Cu 2 O nanoparticles for N-atom insertion reactions: a base-free synthesis of quinazolinones with a green approach

R Thrilokraj, JG Małecki, S Budagumpi… - Green …, 2024 - pubs.rsc.org
The present study describes the use of a novel and eco-friendly biogenic approach for the
synthesis of copper oxide nanoparticles (Cu2O NPs) utilizing Cucumis melo (musk melon) …

A Copper‐Catalyzed Interrupted Domino Reaction for the Synthesis of Fused Triazolyl Benzothiadiazine‐1‐oxides

R Hommelsheim, S Bausch… - … A European Journal, 2023 - Wiley Online Library
Copper (I)‐catalyzed domino reactions of 2‐azido sulfoximines with 1‐iodoalkynes yield
fused triazolyl‐containing benzothiadiazine‐1‐oxides. The protocol features the synthesis of …

Fused Imidazo [2, 1‐b][1, 2, 3] triazolo [4, 5‐d][1, 3] thiazines: One‐Pot Synthesis, Antibiofilim, Bactericidal Effects, and in silico Studies

N Ramu, TM Krishna, V Nasipireddy… - …, 2023 - Wiley Online Library
It has been reported that biologically active organic probe underwent a highly adaptive,
efficient and selective “Click followed by C− N bond coupling” by the use of PEG‐400 in …

Divergent cyclization of 2-(5-iodo-1, 2, 3-triazolyl) benzamides toward triazole-fused lactams and cyclic imidates

YN Kotovshchikov, SS Tatevosyan… - New Journal of …, 2023 - pubs.rsc.org
Universal divergent approaches to 1, 2, 3-triazole-fused quinazolinones and benzoxazine
imines have been developed. Both utilize the intramolecular base-mediated cyclization of …