Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Astrocytes regulate synaptic communication and are essential for proper brain functioning.
In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an …

Unpredictable chronic mild stress (UCMS) is one of the most commonly used, robust and
translatable models for studying the neurobiological basis of major depression. Although the …

Early-life stress (ELS) leads to increased vulnerability to psychiatric disorders including
depression later in life. Neuroinflammatory processes have been implicated in ELS-induced …

Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative
pathologies, but the molecular and cellular changes underlying pathological aging of the …

Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …

Inflammation is a crucial component that contributes to the pathogenesis of major
depressive disorder. It has been revealed that the nonselective cation channel transient …

Severe stress is among the most robust risk factors for the development of psychiatric
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …

Adverse experiences during childhood are among the most prominent risk factors for
developing mood and anxiety disorders later in life. Early-life stress interventions have been …

The dentate gyrus (DG), an important part of the hippocampus, plays a significant role in
learning, memory, and emotional behavior. Factors potentially influencing normal …