The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis
P Schimmel - Nature reviews Molecular cell biology, 2018 - nature.com
The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …
Deciphering the tRNA-derived small RNAs: origin, development, and future
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the …
Perturbation-response genes reveal signaling footprints in cancer gene expression
M Schubert, B Klinger, M Klünemann, A Sieber… - Nature …, 2018 - nature.com
Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …
research. A common approach is to infer signaling activity of pathways from gene …
Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement
Upon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-
derived fragments (tRFs). We identify a novel class of tRFs derived from tRNA Glu, tRNA …
derived fragments (tRFs). We identify a novel class of tRFs derived from tRNA Glu, tRNA …
A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1
E Zhang, X He, C Zhang, J Su, X Lu, X Si, J Chen… - Genome biology, 2018 - Springer
Background Recently, increasing evidence shows that long noncoding RNAs (lncRNAs)
play a significant role in human tumorigenesis. However, the function of lncRNAs in human …
play a significant role in human tumorigenesis. However, the function of lncRNAs in human …
Minimizing the damage: repair pathways keep mitochondrial DNA intact
Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …
accurate replication, transmission and preservation of its integrity throughout the life of the …
Cross-tissue analysis of gene and protein expression in normal and cancer tissues
The central dogma of molecular biology describes the translation of genetic information from
mRNA to protein, but does not specify the quantitation or timing of this process across the …
mRNA to protein, but does not specify the quantitation or timing of this process across the …
NF-Y and the transcriptional activation of CCAAT promoters
D Dolfini, R Gatta, R Mantovani - Critical reviews in biochemistry …, 2012 - Taylor & Francis
The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …
were among the first cis-elements and trans-acting factors identified; their interplay is …
Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
A Diaz-Lagares, AB Crujeiras… - Proceedings of the …, 2016 - National Acad Sciences
Long noncoding RNAs (lncRNAs) are important regulators of cellular homeostasis.
However, their contribution to the cancer phenotype still needs to be established. Herein, we …
However, their contribution to the cancer phenotype still needs to be established. Herein, we …
YB-1: oncoprotein, prognostic marker and therapeutic target?
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …
changes required for the development and persistence of tumours [Hanahan and Weinberg …