Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Outbreaks of severe virus infections with the potential to cause global pandemics are
increasing. In many instances these outbreaks have been newly emerging (SARS …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Type I interferons (IFN-α/β) are potent antiviral cytokines and modulators of the adaptive
immune system. They are induced by viral infection or by double-stranded RNA (dsRNA), a …

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor
that produced IFN-I and regulated innate immune response, subsequent studies have …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Epstein-Bar virus (EBV) is widespread within the human population with over 90% of adults
being infected. In response to primary EBV infection, the host mounts an antiviral immune …

Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of
global mortality. Acute exacerbations of COPD frequently necessitate hospital admission to …

Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as …

Viral infection triggers an early host response through activation of pattern recognition
receptors, including Toll-like receptors (TLR). TLR signaling cascades induce production of …