Insertion sequences

J Mahillon, M Chandler - Microbiology and molecular biology …, 1998 - Am Soc Microbiol
Insertion sequences (ISs) constitute an important component of most bacterial genomes.
Over 500 individual ISs have been described in the literature to date, and many more are …

DNA transposons: nature and applications in genomics

M Muñoz-López, JL García-Pérez - Current genomics, 2010 - ingentaconnect.com
Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes

PD Fey, JL Endres, VK Yajjala, TJ Widhelm, RJ Boissy… - MBio, 2013 - Am Soc Microbiol
To enhance the research capabilities of investigators interested in Staphylococcus aureus,
the Nebraska Center for Staphylococcal Research (CSR) has generated a sequence …

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

JE Griffin, JD Gawronski, MA DeJesus… - PLoS …, 2011 - journals.plos.org
The pathways that comprise cellular metabolism are highly interconnected, and alterations
in individual enzymes can have far-reaching effects. As a result, global profiling methods …

Genes required for mycobacterial growth defined by high density mutagenesis

CM Sassetti, DH Boyd, EJ Rubin - Molecular microbiology, 2003 - Wiley Online Library
Despite over a century of research, tuberculosis remains a leading cause of infectious death
worldwide. Faced with increasing rates of drug resistance, the identification of genes that are …

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

T Van Opijnen, KL Bodi, A Camilli - Nature methods, 2009 - nature.com
Biological pathways are structured in complex networks of interacting genes. Solving the
architecture of such networks may provide valuable information, such as how …

[HTML][HTML] Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

Z Ivics, PB Hackett, RH Plasterk, Z Izsvák - Cell, 1997 - cell.com
Members of the Tc1/mariner superfamily of transposons isolated from fish appear to be
transpositionally inactive due to the accumulation of mutations. Molecular phylogenetic data …

Plant transposable elements: where genetics meets genomics

C Feschotte, N Jiang, SR Wessler - Nature Reviews Genetics, 2002 - nature.com
Transposable elements are the single largest component of the genetic material of most
eukaryotes. The recent availability of large quantities of genomic sequence has led to a shift …

Identifying genetic determinants needed to establish a human gut symbiont in its habitat

AL Goodman, NP McNulty, Y Zhao, D Leip, RD Mitra… - Cell host & …, 2009 - cell.com
The human gut microbiota is a metabolic organ whose cellular composition is determined by
a dynamic process of selection and competition. To identify microbial genes required for …

Insights into mammalian TE diversity through the curation of 248 genome assemblies

AB Osmanski, NS Paulat, J Korstian, JR Grimshaw… - Science, 2023 - science.org
We examined transposable element (TE) content of 248 placental mammal genome
assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that …