Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to
cells due to the excessive generation of highly reactive oxygen (ROS) and nitrogen (RNS) …

Copper (Cu), a redox active metal, is an essential nutrient for all species studied to date.
During the past decade, there has been increasing interest in the concept that marginal …

Oxidative modification of LDL is known to elicit an array of pro-atherogenic responses, but it
is generally underappreciated that oxidized LDL (OxLDL) exists in multiple forms …

Copper and iron are essential but also toxic metals. Their essentiality is known, but their
toxicity, except for the genetic overload diseases, Wilson's disease and hemochromatosis, is …

The literature relating lipid and lipoprotein oxidation to atherosclerosis has expanded
enormously in recent years. Papers on the “oxidative modification hypothesis” of …

Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation,
respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is …

The effects of long-term dietary administration of corticosterone (CORT) on the induction of
oxidative injury in broiler chickens (Gallus gallus domesticus) were evaluated. The …

Copper is an essential micronutrient for human bodies, whose distribution in different organs
and tissues, metabolism and physiological impact is not thoroughly explained yet. Further …

Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish
the disease burden. New strategies to treat or prevent heart failure are urgently needed …

In this review, we point out that natural selection does not act to lessen human diseases after
the reproductive and caregiving period and that normal levels of iron and copper that may …