Challenges of applying multicellular tumor spheroids in preclinical phase
SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …
becoming an essential tool in cancer research as it expresses an intermediate complexity …
Three-dimensional spheroids as in vitro preclinical models for cancer research
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority …
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs
AS Nunes, AS Barros, EC Costa… - Biotechnology and …, 2019 - Wiley Online Library
Three‐dimensional cell culture models, such as spheroids, can be used in the process of the
development of new anticancer agents because they are able to closely mimic the main …
development of new anticancer agents because they are able to closely mimic the main …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
Rationally designed drug delivery systems for the local treatment of resected glioblastoma
Glioblastoma (GBM) is a particularly aggressive brain cancer associated with high
recurrence and poor prognosis. The standard of care, surgical resection followed by …
recurrence and poor prognosis. The standard of care, surgical resection followed by …
Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche
The failure of the osteosarcoma conventional therapies leads to the growing need for novel
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …
3D tumour spheroids for the prediction of the effects of radiation and hyperthermia treatments
For multimodality therapies such as the combination of hyperthermia and radiation,
quantification of biological effects is key for dose prescription and response prediction …
quantification of biological effects is key for dose prescription and response prediction …
Reduction of human glioblastoma spheroids using cold atmospheric plasma: The combined effect of short-and long-lived reactive species
Cold atmospheric plasma (CAP) is a promising technology against multiple types of cancer.
However, the current findings on the effect of CAP on two-dimensional glioblastoma cultures …
However, the current findings on the effect of CAP on two-dimensional glioblastoma cultures …
Microwell array chip-based single-cell analysis
Single-cell profiling is key to uncover the cellular heterogeneity and drives deep
understanding of cell fate. In recent years, microfluidics has become an ideal tool for single …
understanding of cell fate. In recent years, microfluidics has become an ideal tool for single …
3D hanging spheroid plate for high-throughput CAR T cell cytotoxicity assay
Background Most high-throughput screening (HTS) systems studying the cytotoxic effect of
chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture …
chimeric antigen receptor (CAR) T cells on tumor cells rely on two-dimensional cell culture …