Towards FLASH proton therapy: the impact of treatment planning and machine characteristics on achievable dose rates
S Van De Water, S Safai, JM Schippers… - Acta …, 2019 - Taylor & Francis
Background: This study aimed at evaluating spatially varying instantaneous dose rates for
different intensity-modulated proton therapy (IMPT) planning strategies and delivery …
different intensity-modulated proton therapy (IMPT) planning strategies and delivery …
New horizons in particle therapy systems
Particle therapy is rapidly expanding and claiming its position as the treatment modality of
choice in teletherapy. However, the rate of expansion continues to be restricted by the size …
choice in teletherapy. However, the rate of expansion continues to be restricted by the size …
A quantitative FLASH effectiveness model to reveal potentials and pitfalls of high dose rate proton therapy
M Krieger, S van de Water, MM Folkerts… - Medical …, 2022 - Wiley Online Library
Purpose In ultrahigh dose rate radiotherapy, the FLASH effect can lead to substantially
reduced healthy tissue damage without affecting tumor control. Although many studies show …
reduced healthy tissue damage without affecting tumor control. Although many studies show …
Preclinical challenges in proton minibeam radiotherapy: physics and biomedical aspects
G Datzmann, M Sammer, S Girst, M Mayerhofer… - Frontiers in …, 2020 - frontiersin.org
The concept of spatial fractionation in radiotherapy was developed for better sparing of
normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton …
normal tissue in the entrance channel of radiation. Spatial fractionation utilizing proton …
A novel approach to seamless simulations of compact hadron therapy systems for self-consistent evaluation of dosimetric and radiation protection quantities
C Hernalsteens, R Tesse, ST Boogert… - Europhysics …, 2020 - iopscience.iop.org
Hadron therapy installations are evolving towards more compact systems that require higher-
quality beams for advanced treatment modalities such as proton flash and arc therapy …
quality beams for advanced treatment modalities such as proton flash and arc therapy …
[HTML][HTML] A dynamic collimation and alignment system for the Helmholtz linear accelerator
S Lauber, K Aulenbacher, W Barth, M Basten… - Review of Scientific …, 2021 - pubs.aip.org
The upcoming commissioning of the superconducting (SC) continuous wave Helmholtz
linear accelerators first of series cryomodule is going to demand precise alignment of the …
linear accelerators first of series cryomodule is going to demand precise alignment of the …
[HTML][HTML] Probing the losses for a high power beam
MH Tahar, D Kiselev, A Knecht, D Laube… - Nuclear Instruments and …, 2023 - Elsevier
Abstract The High Intensity Proton Accelerator (HIPA) cyclotron at the Paul Scherrer Institut
(PSI) delivers 590 MeV CW proton beam with a maximum power of 1.42 MW. After …
(PSI) delivers 590 MeV CW proton beam with a maximum power of 1.42 MW. After …
[HTML][HTML] Beamline characterization of a dielectric-filled reentrant cavity resonator as beam current monitor for a medical cyclotron facility
S Srinivasan, PA Duperrex, JM Schippers - Physica Medica, 2020 - Elsevier
Abstract At PSI (Paul Scherrer Institute), Switzerland, a superconducting cyclotron called
“COMET” delivers proton beam of 250 MeV pulsed at 72.85 MHz for proton radiation …
“COMET” delivers proton beam of 250 MeV pulsed at 72.85 MHz for proton radiation …
[HTML][HTML] A hybrid numerical approach to the propagation of charged particle beams through matter for hadron therapy beamline simulations
C Hernalsteens, R Tesse, E Gnacadja, N Pauly… - Nuclear Instruments and …, 2022 - Elsevier
In hadron therapy beamlines, passive elements are used to reduce the beam energy or to
shape its transverse profile and frequently complement the magnetic transport channel …
shape its transverse profile and frequently complement the magnetic transport channel …
An FFT-based beam profile denoising method for beam profile distortion correction
Y Lin, P Tan, D Li, X Wang, X Shen - Nuclear Instruments and Methods in …, 2023 - Elsevier
The accurate verification of beam parameters is mandatory for treatment safety in particle
therapy, therefore, the systematic uncertainties of the segmented ionization chambers and …
therapy, therefore, the systematic uncertainties of the segmented ionization chambers and …