Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice …

Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol,
viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell …

Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and
regulators. It is the most common cause of acute liver failure in the US. It is also one of the …

Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the
market and although infrequent, DILI can result in serious clinical outcomes including acute …

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The low incidence of idiosyncratic drug-induced liver injury (DILI), together with the lack of a
reliable diagnostic biomarker and robust preclinical and in vitro toxicology test systems for …