Inorganic polyphosphates (polyP) are linear polymers of tens to hundreds orthophosphate
residues linked by phosphoanhydride bonds. These fairly abundant biopolymers occur in all …

Inorganic polyphosphate (polyP) accumulates in acidocalcisomes, acidic calcium stores that
have been found from bacteria to human cells. Proton pumps, such as the vacuolar proton …

Trypanosoma cruzi, the flagellate protozoan agent of Chagas disease or American
trypanosomiasis, is unable to synthesize sialic acids de novo. Mucins and trans-sialidase …

Acidocalcisomes are acidic organelles present in a diverse range of organisms from
bacteria to human cells. In this study acidocalcisomes were purified from the model …

Parasitic diseases caused by protozoans are highly prevalent around the world,
disproportionally affecting developing countries, where coinfection with other …

While free-living protists are usually subjected to hyposmotic environments, parasitic protists
are also in contact with hyperosmotic habitats. Recent work in one of these parasites …

Background Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, remains
an important public health issue in many Central and South American countries, as well as …

Protozoan parasites have a significant impact upon global health, infecting millions of
people around the world. With limited therapeutic options and no vaccines available …

Trypanosoma cruzi is a unicellular parasite and the etiologic agent of Chagas disease. The
parasite has a digenetic life cycle alternating between mammalian and insect hosts, where it …

The flagellated kinetoplastid protozoan and causative agent of human Chagas disease,
Trypanosoma cruzi, inhabits both invertebrate and mammalian hosts over the course of its …