Drug metabolism in the liver

OA Almazroo, MK Miah… - Clinics in liver …, 2017 - liver.theclinics.com
Drugs are typically small molecules that are generally classified as xenobiotics, which are
foreign to the human body. Several endogenous molecules, however, such as steroids and …

Metabolite identification by liquid chromatography-mass spectrometry

B Prasad, A Garg, H Takwani, S Singh - TrAC Trends in Analytical …, 2011 - Elsevier
Metabolite identification (Met ID) is important during the early stages of drug discovery and
development, as the metabolic products may be pharmacologically active or toxic in nature …

Salidroside-can it be a multifunctional drug?

SKJ Magani, SD Mupparthi, BP Gollapalli… - Current Drug …, 2020 - ingentaconnect.com
Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It
exhibits diverse biological and pharmacological properties. In the last decade, enormous …

Determination and identification of antibiotic drugs and bacterial strains in biological samples

K Pauter, M Szultka-Młyńska, B Buszewski - Molecules, 2020 - mdpi.com
Antibiotics were initially natural substances. However, nowadays, they also include synthetic
drugs, which show their activity against bacteria, killing or inhibiting their growth and …

Quantification of polychlorinated biphenyls and polybrominated diphenyl ethers in commercial cows' milk from California by gas chromatography–triple quadruple …

X Chen, Y Lin, K Dang, B Puschner - PloS one, 2017 - journals.plos.org
We determined 12 polybrominated diphenyl ethers (PBDEs) and 19 polychlorinated
biphenyls (PCBs) congeners in eight different brands of commercial whole milk (WM) and fat …

Herbal medicines in Brazil: pharmacokinetic profile and potential herb-drug interactions

ALDA Mazzari, JM Prieto - Frontiers in Pharmacology, 2014 - frontiersin.org
A plethora of active compounds found in herbal medicines can serve as substrate for
enzymes involved in the metabolism of xenobiotics. When a medicinal plant is co …

Pharmacogenetics of adverse drug reactions

O Osanlou, M Pirmohamed, AK Daly - Advances in Pharmacology, 2018 - Elsevier
Adverse drug reactions (ADRs) are an important cause of morbidity and mortality. Genetic
factors predispose to many ADRs, affecting susceptibility to both type A and type B reactions …

The challenge of developing green tea polyphenols as therapeutic agents

C Huo, SB Wan, WH Lam, L Li, Z Wang… - …, 2008 - Springer
The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-
EGCG] have been widely supported by results from epidemiological, cell culture, animal and …

Traditional and ethnobotanical dermatology practices in Africa

NC Dlova, MA Ollengo - Clinics in Dermatology, 2018 - Elsevier
More than 80% of the global population depends on traditional medicine for their basic
primary health care needs. Africa has a well-established history of botanicals use. These …

Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells

TJ DiProspero, E Dalrymple, MR Lockett - Toxicology in Vitro, 2021 - Elsevier
This study evaluates the impact of physiologically relevant oxygen tensions on the response
of HepG2 cells to known inducers and hepatotoxic drugs. We compared transcriptional …