Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Platelets have been widely recognized as a bona fide mediator of malignant diseases, and
they play significant roles in influencing various aspects of tumor progression. Paracrine …

Metastatic dissemination accounts for most of the death in patients during cancer
progression. There is thus an urge to identify specific biomarkers as proxies for cancer …

Background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer
(LC), which is the leading cause of tumor mortality. In recent years, compared with tissue …

Adhesion G protein-coupled receptors (aGPCR) are unique molecules. They are able to
transmit classical signals via G-protein activation (7TM-dependent/cis signaling) as well as …