Lung cancer is the number one cancer killer in the United States. This disease is clinically
divided into two sub-types, small cell lung cancer,(10–15% of lung cancer cases), and non …

Genetic changes through allelic loss and nucleic acid or protein modifications are the main
contributors to loss of function of tumor suppressor proteins. In particular, epigenetic …

Lung cancer is indeed a major cause of cancer‐related deaths worldwide. The development
of tumors involves a complex interplay of genetic, epigenetic, and environmental factors …

There are six core RASSF family proteins that contain conserved Ras Association domains
and may serve as Ras effectors. They lack intrinsic enzymatic activity and appear to function …

The epigenetic silencing of tumor suppressor genes is a crucial event during carcinogenesis
and metastasis. Here, in a human genome-wide survey, we identified scavenger receptor …

DNA methylation is part of the epigenetic gene regulation complex, which is relevant for the
pathogenesis of cancer. We performed a genome-wide search for methylated CpG islands …

Endometriosis is a complex and common gynecological disorder yet a poorly understood
disease affecting about 176 million women worldwide and causing significant impact on …

Changes in the genome which result in cancer promotion remain a complex interplay of
aberrant methylation in the setting of a multitude of epigenetic changes. The events leading …

Abstract Cancer-associated fibroblasts (CAFs), a major component of cancer stroma, play an
important role in cancer progression but little is known about how CAFs affect tumorigenesis …

RASSF2 is a tumour suppressor that in common with the rest of the RASSF family contains
Ras association and SARAH domains. We identified the proapoptotic kinases, MST1 and …