Quantitative SARS-CoV-2 viral-load curves in paired saliva samples and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity …

ES Savela, A Viloria Winnett, AE Romano… - Journal of clinical …, 2022 - Am Soc Microbiol
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and
presymptomatic transmission, curb the spread of variants, and maximize treatment efficacy …

Surface and air contamination with severe acute respiratory syndrome coronavirus 2 from hospitalized coronavirus disease 2019 patients in Toronto, Canada, March …

JD Kotwa, AJ Jamal, H Mbareche, L Yip… - The Journal of …, 2022 - academic.oup.com
Background We determined the burden of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in air and on surfaces in rooms of patients hospitalized with coronavirus …

[HTML][HTML] SPLASH: a statistical, reference-free genomic algorithm unifies biological discovery

K Chaung, TZ Baharav, G Henderson, IN Zheludev… - Cell, 2023 - cell.com
Today's genomics workflows typically require alignment to a reference sequence, which
limits discovery. We introduce a unifying paradigm, SPLASH (Statistically Primary aLignment …

Surface and air contamination with SARS-CoV-2 from hospitalized COVID-19 patients in Toronto, Canada

JD Kotwa, AJ Jamal, H Mbareche, L Yip, P Aftanas… - MedRXiv, 2021 - medrxiv.org
Background The aim of this prospective cohort study was to determine the burden of SARS-
CoV-2 in air and on surfaces in rooms of patients hospitalized with COVID-19, and to identify …

Performance of the Diasorin SARS-CoV-2 antigen detection assay on the LIAISON XL

N Van der Moeren, VF Zwart, G Goderski… - Journal of Clinical …, 2021 - Elsevier
Background The current reference standard to diagnose a SARS-CoV-2 infection is real-
time reverse transcriptase polymerase chain reaction (RT-PCR). This test poses substantial …

[PDF][PDF] SARS-CoV-2 is detectable using sensitive RNA saliva testing days before viral load reaches detection range of low-sensitivity nasal swab tests

ES Savela, A Winnett, AE Romano, MK Porter… - medRxiv, 2021 - scienceopen.com
Early detection of SARS-CoV-2 infection is critical to reduce asymptomatic and pre-
symptomatic spread of COVID-19, curb the spread of viral variants by travelers, and …

[HTML][HTML] Specific splice junction detection in single cells with SICILIAN

R Dehghannasiri, JE Olivieri, A Damljanovic… - Genome Biology, 2021 - Springer
Precise splice junction calls are currently unavailable in scRNA-seq pipelines such as the
10x Chromium platform but are critical for understanding single-cell biology. Here, we …

A statistical, reference-free algorithm subsumes myriad problems in genome science and enables novel discovery

K Chaung, T Baharav, I Zheludev, J Salzman - BioRxiv, 2022 - biorxiv.org
We present a unifying statistical formulation for many fundamental problems in genome
science and develop a reference-free, highly efficient algorithm that solves it. Sequence …

Diagnostic applications for RNA-Seq technology and transcriptome analyses in human diseases caused by RNA viruses

IVS Louis, A Gorzalski, M Pandori - … of RNA-Seq in Biology and …, 2021 - books.google.com
Human diseases caused by single-stranded, positive-sense RNA viruses, are among the
deadliest of the 21st Century. In particular, there are two notable standouts: human …

Effectiveness, safety, and efficiency of a drive‐through care model as a response to the COVID‐19 testing demand in the United States

S Ravi, A Graber‐Naidich… - Journal of the …, 2022 - Wiley Online Library
Objectives Here we report the clinical performance of COVID‐19 curbside screening with
triage to a drive‐through care pathway versus main emergency department (ED) care for …