It is estimated that Asia will be the home of more than 100 million people with type 2
diabetes by the year of 2025. This region combines a high proportion of the world's …

Sarcopenia is a systemic disease with progressive and generalized skeletal muscle
dysfunction defined by age-related low muscle mass, high content of muscle slow fibers, and …

Appendicular lean mass (ALM) is a heritable trait associated with loss of lean muscle mass
and strength, or sarcopenia, but its genetic determinants are largely unknown. Here we …

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We
performed a genome-wide association study for whole body (20 cohorts of European …

Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide
problem. Although multiple genetic loci associated with body mass index, the most common …

Population stratification is a potential problem for genome-wide association studies (GWAS),
confounding results and causing spurious associations. Hence, understanding how allele …

OBJECTIVE: Sarcopenia of legs is an important cause of physical dysfunctions, frailty and
dependence. Many predisposing and underlying mechanisms of sarcopenia, including age …

The substantial decline in skeletal muscle mass, strength, and gait speed is a sign of severe
sarcopenia, which may partly depend on genetic risk factors. So far, hundreds of genome …

Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …

Deep sequence-based imputation can enhance the discovery power of genome-wide
association studies by assessing previously unexplored variation across the common-and …